| 产品: | SSR1 抗体 |
| 货号: | DF8244 |
| 描述: | Rabbit polyclonal antibody to SSR1 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 32 kDa; 32kD(Calculated). |
| 蛋白号: | P43307 |
| RRID: | AB_2841539 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8244, RRID:AB_2841539.
展开/折叠
DKFZp781N23103; FLJ14232; FLJ22100; FLJ23034; FLJ78242; FLJ93042; PGP35; Signal sequence receptor alpha; Signal sequence receptor alpha subunit; Signal sequence receptor subunit alpha; SSR 1; SSR alpha; SSR-alpha; SSR1; SSRA_HUMAN; SSRalpha; Translocon associated protein alpha; Translocon associated protein alpha subunit; Translocon associated protein subunit alpha; Translocon-associated protein subunit alpha; TRAP a; TRAP-alpha; TRAPa; TRAPalpha;
抗原和靶标
- P43307 SSRA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P43307 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S80 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| N136 | N-Glycosylation | Uniprot | |
| Y156 | Phosphorylation | Uniprot | |
| N191 | N-Glycosylation | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| S268 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S281 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot |
研究背景
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
Belongs to the TRAP-alpha family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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