| 产品: | HYOU1 抗体 |
| 货号: | DF8329 |
| 描述: | Rabbit polyclonal antibody to HYOU1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Monkey |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 111 kDa; 111kD(Calculated). |
| 蛋白号: | Q9Y4L1 |
| RRID: | AB_2841601 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8329, RRID:AB_2841601.
展开/折叠
150 kDa oxygen regulated protein; 150 kDa oxygen-regulated protein; 170 kDa glucose regulated protein; 170 kDa glucose-regulated protein; DKFZp686N08236; FLJ94899; FLJ97572; glucose regulated protein 170; Grp 170; GRP-170; Grp170; HSP 12A; HSP12A; Hyou1; HYOU1_HUMAN; Hypoxia up regulated 1; hypoxia up-regulated 1 precursor; Hypoxia up-regulated protein 1; Hypoxia upregulated 1; Orp 150; ORP-150; Orp150; oxygen regulated protein (150kD);
抗原和靶标
Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
- Q9Y4L1 HYOU1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y4L1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K51 | Ubiquitination | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| R79 | Methylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| N155 | N-Glycosylation | Uniprot | |
| K198 | Acetylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| R262 | Methylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| R278 | Methylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| Y421 | Phosphorylation | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| Y443 | Phosphorylation | Uniprot | |
| K463 | Acetylation | Uniprot | |
| K463 | Ubiquitination | Uniprot | |
| N515 | N-Glycosylation | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| K529 | Ubiquitination | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| T580 | O-Glycosylation | Uniprot | |
| T589 | O-Glycosylation | Uniprot | |
| T590 | O-Glycosylation | Uniprot | |
| T590 | Phosphorylation | Uniprot | |
| N596 | N-Glycosylation | Uniprot | |
| T600 | Phosphorylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| T727 | Phosphorylation | Uniprot | |
| K738 | Ubiquitination | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| K753 | Ubiquitination | Uniprot | |
| Y759 | Phosphorylation | Uniprot | |
| S763 | Phosphorylation | Uniprot | |
| N830 | N-Glycosylation | Uniprot | |
| T850 | Phosphorylation | Uniprot | |
| N862 | N-Glycosylation | Uniprot | |
| N869 | N-Glycosylation | Uniprot | |
| R900 | Methylation | Uniprot | |
| Y904 | Phosphorylation | Uniprot | |
| N931 | N-Glycosylation | Uniprot | |
| T948 | Phosphorylation | Uniprot | |
| S955 | Phosphorylation | Uniprot |
研究背景
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
Endoplasmic reticulum lumen.
Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Belongs to the heat shock protein 70 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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