| 产品: | HES6 抗体 |
| 货号: | DF8664 |
| 描述: | Rabbit polyclonal antibody to HES6 |
| 应用: | WB IF/ICC |
| 反应: | Human, Rat |
| 预测: | Pig, Bovine |
| 分子量: | 24kDa,27kDa; 24kD(Calculated). |
| 蛋白号: | Q96HZ4 |
| RRID: | AB_2841868 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8664, RRID:AB_2841868.
展开/折叠
bHLHb41; bHLHc23; C HAIRY1; Class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; Hairy/enhancer of split 6, Drosophila, homolog of, 6; HES 6; hes family bHLH transcription factor 6; Transcription cofactor HES6;
抗原和靶标
- Q96HZ4 HES6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Nucleus.
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with HES1 (By similarity).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
研究领域
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
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