| 产品: | ABCB8 抗体 |
| 货号: | DF9249 |
| 描述: | Rabbit polyclonal antibody to ABCB8 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 分子量: | 80 kDa; 80kD(Calculated). |
| 蛋白号: | Q9NUT2 |
| RRID: | AB_2842445 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9249, RRID:AB_2842445.
展开/折叠
;ATP binding cassette sub family B member 8; ABCB8; ABCB8_HUMAN; ATP binding cassette sub family B (MDR/TAP) member 8; ATP binding cassette sub family B member 8 mitochondrial; ATP-binding cassette sub-family B member 8; EST328128; M ABC1; M-ABC1; MABC1; Mitochondrial ABC protein; mitochondrial; Mitochondrial ATP binding cassette 1; Mitochondrial ATP-binding cassette 1;
抗原和靶标
- Q9NUT2 MITOS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS
翻译修饰 - Q9NUT2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S84 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| T295 | Phosphorylation | Uniprot | |
| T310 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K513 | Ubiquitination | Uniprot | |
| T540 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| K628 | Ubiquitination | Uniprot | |
| K699 | Ubiquitination | Uniprot |
研究背景
ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
Mitochondrion inner membrane>Multi-pass membrane protein.
Ubiquitous.
The mitochondrial potassium channel (mitoK(ATP)) is composed of 4 subunits of CCDC51/MITOK and 4 subunits of ABCB8/MITOSUR (Probable). Interacts with C10orf88/PAAT. Interacts with NRP1; NRP1 regulates ABCB8/MITOSUR protein levels in mitochondria.
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
研究领域
· Environmental Information Processing > Membrane transport > ABC transporters.
限制条款
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