(2)
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| 产品: | LILRB2 抗体 |
| 货号: | DF9604 |
| 描述: | Rabbit polyclonal antibody to LILRB2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 60~80 kDa; 65kD(Calculated). |
| 蛋白号: | Q8N423 |
| RRID: | AB_2842800 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9604, RRID:AB_2842800.
展开/折叠
CD85 antigen-like family member D; CD85d; CD85d antigen; ILT 4; ILT-4; ILT4; Immunoglobulin like transcript 4; Immunoglobulin-like transcript 4; Leukocyte immunoglobulin like receptor 2; Leukocyte immunoglobulin like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor 2; Leukocyte immunoglobulin-like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRA6; LILRB2; LIR 2; LIR-2; LIR2; LIRb; LIRB2_HUMAN; MIR 10; MIR-10; MIR10; Monocyte/macrophage immunoglobulin like receptor 10; Monocyte/macrophage immunoglobulin-like receptor 10;
抗原和靶标
Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid-derived suppressor cells during pregnancy (PubMed:27859042). Detected at low levels in natural killer (NK) cells. Expressed in B cells.
- Q8N423 LIRB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTPIVTVLICLGLSLGPRTHVQTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEEEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVVAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPAGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVVLLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKDTQPEDGVEMDTRAAASEAPQDVTYAQLHSLTLRRKATEPPPSQEREPPAEPSIYATLAIH
翻译修饰 - Q8N423 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S66 | Phosphorylation | Uniprot | |
| T71 | Phosphorylation | Uniprot | |
| Y377 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| Y533 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| Y562 | Phosphorylation | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| Y592 | Phosphorylation | Uniprot |
研究背景
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Cell membrane>Single-pass type I membrane protein.
Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK) cells. Expressed in B cells.
Binds PTPN6 when phosphorylated. Binds FCGR1A. Interacts with peptide-bound HLA-G-B2M; this interaction is direct. Interacts with peptide-bound HLA-F-B2M; this interaction is direct.
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
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