| 产品: | RASA4 抗体 |
| 货号: | DF9805 |
| 描述: | Rabbit polyclonal antibody to RASA4 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Zebrafish, Chicken, Xenopus |
| 分子量: | 90 kDa; 90kD(Calculated). |
| 蛋白号: | O43374 |
| RRID: | AB_2842999 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9805, RRID:AB_2842999.
展开/折叠
Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; GTPase activating protein like; KIAA0538; MGC131890; Ras GTPase activating protein 4; RAS p21 protein activator 4; RasGAP activating like protein 2;
抗原和靶标
- O43374 RASL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43374 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K33 | Ubiquitination | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| Y381 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| S476 | Phosphorylation | Uniprot | |
| S481 | Phosphorylation | Uniprot | |
| K505 | Ubiquitination | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| S595 | Phosphorylation | Uniprot | |
| S760 | Phosphorylation | Uniprot |
研究背景
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Cytoplasm>Cytosol. Cell membrane>Peripheral membrane protein.
Note: Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Widely expressed.
The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
研究领域
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
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