| 产品: | FKBP4 抗体 |
| 货号: | AF7565 |
| 描述: | Rabbit polyclonal antibody to FKBP4 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 51kDa; 52kD(Calculated). |
| 蛋白号: | Q02790 |
| RRID: | AB_2843929 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7565, RRID:AB_2843929.
展开/折叠
51 kDa FK506-binding protein; 52 kDa FK506 binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4; FK506-binding protein 4; FKBP 4; FKBP 52; FKBP 59; FKBP-4; FKBP-52; FKBP4; FKBP4_HUMAN; FKBP51; FKBP52 protein; FKBP59; HBI; Hsp 56; HSP binding immunophilin; HSP-binding immunophilin; Hsp56; Immunophilin FKBP52; N-terminally processed; p52; p59; p59 protein; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP4; Peptidylprolyl cis trans isomerase; PPIase; PPIase FKBP4; Rotamase; T cell FK506 binding protein 59kD;
抗原和靶标
- Q02790 FKBP4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q02790 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T9 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K28 | Acetylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| R52 | Methylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| K76 | Acetylation | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| T143 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| Y161 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| K222 | Acetylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| K232 | Acetylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| K274 | Acetylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| K282 | Acetylation | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| K294 | Acetylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| K354 | Acetylation | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| R359 | Methylation | Uniprot | |
| R373 | Methylation | Uniprot | |
| K378 | Acetylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| C396 | S-Nitrosylation | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| Y411 | Phosphorylation | Uniprot | |
| R417 | Methylation | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| T436 | Phosphorylation | Uniprot | |
| T438 | Phosphorylation | Uniprot | |
| K441 | Sumoylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| T448 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| S453 | Phosphorylation | Uniprot |
研究背景
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Phosphorylation by CK2 results in loss of HSP90 binding activity.
Cytoplasm>Cytosol. Mitochondrion. Nucleus. Cytoplasm>Cytoskeleton. Cell projection>Axon.
Note: Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
Widely expressed.
Homodimer (By similarity). Interacts with GLMN. Associates with HSP90AA1 and HSP70 in steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex. Associates with tubulin. Interacts with MAPT/TAU (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction. Interacts with dynein; causes partially NR3C1 transport to the nucleus.
The PPIase activity is mainly due to the first PPIase FKBP-type domain (1-138 AA).
The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
The TPR repeats mediate mitochondrial localization.
研究领域
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
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