产品: Transferrin 抗体
货号: BF0720
描述: Mouse monoclonal antibody to Transferrin
应用: WB
反应: Human
分子量: 77kDa; 77kD(Calculated).
蛋白号: P02787
RRID: AB_2846196

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货

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产品描述

来源:
Mouse
应用:
WB(1:1000-1:10000)
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Monoclonal [AFB17783]
特异性:
Transferrin mouse monoclonal antibody detects endogenous levels of total Transferrin.
RRID:
AB_2846196
引用格式: Affinity Biosciences Cat# BF0720, RRID:AB_2846196.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Apotransferrin;Beta 1 metal binding globulin;Beta-1 metal-binding globulin;DKFZp781D0156;PRO1400;PRO1557;PRO2086;Serotransferrin;Serotransferrin precursor;Siderophilin;TF;TFQTL1;Transferin;Transferrin;TRFE_HUMAN;

抗原和靶标

免疫原:

Purified recombinant fragment of human Trasnferrin expressed in E. Coli.

Uniprot:
基因/基因ID:
表达:
P02787 TRFE_HUMAN:

Expressed by the liver and secreted in plasma.

序列:
MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP

翻译修饰 - P02787 作为底物

Site PTM Type Enzyme
T36 Phosphorylation
K37 Acetylation
C58 S-Nitrosylation
S63 Phosphorylation
Y64 Phosphorylation
S136 Phosphorylation
C137 S-Nitrosylation
T139 Phosphorylation
S144 Phosphorylation
Y155 Phosphorylation
Y207 Phosphorylation
C213 S-Nitrosylation
C246 S-Nitrosylation
Y257 Phosphorylation
C260 S-Nitrosylation
S298 Phosphorylation
S305 Phosphorylation
S306 Phosphorylation
T340 Phosphorylation
T349 Phosphorylation
T355 Phosphorylation
K359 Acetylation
C364 S-Nitrosylation
C374 S-Nitrosylation
S389 Phosphorylation
C396 S-Nitrosylation
S468 Phosphorylation
T476 Phosphorylation
N491 N-Glycosylation
C503 S-Nitrosylation
K508 Acetylation
S520 Phosphorylation
C525 S-Nitrosylation
Y533 Phosphorylation
Y534 Phosphorylation
Y536 Phosphorylation
T537 Phosphorylation
K546 Acetylation
C582 S-Nitrosylation
Y593 Phosphorylation
C596 S-Nitrosylation
T645 Phosphorylation
T654 Phosphorylation
Y666 Phosphorylation
Y669 Phosphorylation
Y674 Phosphorylation
C684 S-Nitrosylation
S685 Phosphorylation
T686 Phosphorylation
S688 Phosphorylation
T694 Phosphorylation

研究背景

功能:

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed by the liver and secreted in plasma.

亚基结构:

Monomer.

蛋白家族:

Belongs to the transferrin family.

研究领域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Organismal Systems > Digestive system > Mineral absorption.

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