产品: SIRT6 抗体
货号: AF6569
描述: Rabbit polyclonal antibody to SIRT6
应用: WB
反应: Human
分子量: 43kDa; 39kD(Calculated).
蛋白号: Q8N6T7
RRID: AB_2847293

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
SIRT6 Antibody detects endogenous levels of total SIRT6.
RRID:
AB_2847293
引用格式: Affinity Biosciences Cat# AF6569, RRID:AB_2847293.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIR6_HUMAN; SIRT 6; SIRT6; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6;

抗原和靶标

免疫原:

A synthesized peptide derived from human SIRT6.

Uniprot:
基因/基因ID:
序列:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS

翻译修饰 - Q8N6T7 作为底物

Site PTM Type Enzyme
S2 Acetylation
S10 Phosphorylation
K17 Ubiquitination
K81 Ubiquitination
K128 Ubiquitination
T146 Phosphorylation
Y148 Phosphorylation
K160 Ubiquitination
T162 Phosphorylation
K170 Ubiquitination
K245 Ubiquitination
K267 Ubiquitination
T294 Phosphorylation
S303 Phosphorylation
T305 Phosphorylation
S310 Phosphorylation
S326 Phosphorylation
S330 Phosphorylation
T337 Phosphorylation
S338 Phosphorylation P31749 (AKT1)

研究背景

功能:

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

细胞定位:

Nucleus>Nucleoplasm.
Note: Predominantly nuclear. Associated with telomeric heterochromatin regions.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.

蛋白家族:

Belongs to the sirtuin family. Class IV subfamily.

研究领域

· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer.   (View pathway)

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