| 产品: | IRF5 抗体 |
| 货号: | AF6907 |
| 描述: | Rabbit polyclonal antibody to IRF5 |
| 应用: | ELISA(peptide) |
| 反应: | Human |
| 分子量: | 55kD,60kD; 56kD(Calculated). |
| 蛋白号: | Q13568 |
| RRID: | AB_2847630 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF6907, RRID:AB_2847630.
展开/折叠
Interferon regulatory factor 5; Interferon regulatory factor 5 bone marrow variant; IRF 5; IRF-5; Irf5; IRF5_HUMAN; SLEB10;
抗原和靶标
A synthesized peptide derived from human IRF5.
- Q13568 IRF5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ
翻译修饰 - Q13568 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T10 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Q9UHD2 (TBK1) | Uniprot |
| S293 | Phosphorylation | Q9UHD2 (TBK1) | Uniprot |
| S301 | Phosphorylation | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| Y335 | Phosphorylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| S435 | Phosphorylation | O43353 (RIPK2) | Uniprot |
| S437 | Phosphorylation | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | O14920 (IKBKB) , O43353 (RIPK2) | Uniprot |
研究背景
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.
Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.
'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.
Cytoplasm. Nucleus.
Note: Shuttles between the nucleus and the cytoplasm.
Homodimer, when phosphorylated.
Belongs to the IRF family.
研究领域
· Organismal Systems > Immune system > Toll-like receptor signaling pathway. (View pathway)
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