产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CASP 2; CASP-2; Casp2; CASP2_HUMAN; Caspase 2; Caspase 2 apoptosis related cysteine peptidase; Caspase-2 subunit p12; Caspase2; ICH 1; ICH 1 protease; ICH 1L; ICH1; ICH1 protease; ICH1L; NEDD-2; NEDD2; Neural precursor cell expressed developmentally down-regulated protein 2; PPP1R57; Protease ICH-1; Protein phosphatase 1 regulatory subunit 57;
抗原和靶标
A synthesized peptide derived from human Caspase 2.
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
- P42575 CASP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
翻译修饰 - P42575 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| R22 | Methylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K77 | Sumoylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| R107 | Methylation | Uniprot | |
| S139 | Phosphorylation | P78527 (PRKDC) | Uniprot |
| Y151 | Phosphorylation | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S157 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T160 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| T374 | Phosphorylation | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| Y420 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot |
研究背景
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress.
The mature protease can process its own propeptide, but not that of other caspases.
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Forms a complex named the PIDDosome with PIDD1 and CRADD. Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner.
The CARD domain mediates a direct interaction with CRADD.
Belongs to the peptidase C14A family.
研究领域
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
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