产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Binding peptide; BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; HPT_HUMAN; MGC111141; Zonulin;
抗原和靶标
- P00738 HPT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
翻译修饰 - P00738 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y55 | Phosphorylation | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| Y66 | Phosphorylation | Uniprot | |
| Y114 | Phosphorylation | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| K170 | Acetylation | Uniprot | |
| N184 | N-Glycosylation | Uniprot | |
| N207 | N-Glycosylation | Uniprot | |
| N211 | N-Glycosylation | Uniprot | |
| N241 | N-Glycosylation | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| C266 | S-Nitrosylation | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| C309 | S-Nitrosylation | Uniprot | |
| K321 | Acetylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| C340 | S-Nitrosylation | Uniprot | |
| C381 | S-Nitrosylation | Uniprot | |
| Y386 | Phosphorylation | Uniprot |
研究背景
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Secreted.
Expressed by the liver and secreted in plasma.
Tetramer of two alpha and two beta chains; disulfide-linked. The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163.
Belongs to the peptidase S1 family.
限制条款
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