产品: Zyxin 小鼠 单克隆 抗体
货号: BF8083
描述: Mouse monoclonal antibody to Zyxin
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 80kDa,70kDa; 61kD(Calculated).
蛋白号: Q15942

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 100ul RMB¥ 688 2300 现货

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产品描述

来源:
Mouse
应用:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Monoclonal [AFfirm8083]
特异性:
Zyxin Antibody detects endogenous levels of total Zyxin.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ESP 2; ESP2; HED 2; HED2; ZYX; ZYX protein; Zyxin 2; Zyxin2;

抗原和靶标

免疫原:

A synthesized peptide derived from human Zyxin, corresponding to a region within the internal amino acids.

Uniprot:
基因/基因ID:
描述:
The zyxin family of proteins includes LIMD1, ajuba, trip6 and zyxin, each of which contains three LIM domains at the carboxy-terminus. Zyxin family members associate with the actin cytoskeleton and are components of both the cell-cell junction adhesive complex and the integrin-mediated adhesive complex. They shuttle in and out of the nucleus where they may function in transcriptional activation (1).Zyxin is involved in the regulation of mechanical force-induced actin polymerization at focal adhesions (2), and in regulation of adhesion and migration, possibly through recruitment of Ena/VASP proteins to focal adhesions (3). Zyxin interacts with and may regulate the function of the tumor suppressor myopodin, which inhibits tumor growth and metastasis (4).
序列:
MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQT

翻译修饰 - Q15942 作为底物

Site PTM Type Enzyme
A2 Acetylation
R5 Methylation
S7 Phosphorylation
S13 Phosphorylation
S15 Phosphorylation
Y20 Phosphorylation
K24 Acetylation
K25 Acetylation
K25 Methylation
S44 Phosphorylation
S116 Phosphorylation
S142 Phosphorylation P31749 (AKT1)
S143 Phosphorylation
S150 Phosphorylation
K165 Acetylation
K165 Methylation
K165 Ubiquitination
S169 Phosphorylation
S170 Phosphorylation
Y172 Phosphorylation
T179 Phosphorylation
K201 Methylation
S202 Phosphorylation
S206 Phosphorylation
T250 Phosphorylation
S258 Phosphorylation
S259 Phosphorylation
K265 Acetylation
K265 Ubiquitination
S267 Phosphorylation
T270 Phosphorylation
K272 Acetylation
K272 Methylation
K272 Ubiquitination
T274 Phosphorylation
S278 Phosphorylation
K279 Acetylation
K279 Methylation
K279 Ubiquitination
S281 Phosphorylation
S288 Phosphorylation
S290 Phosphorylation
K295 Ubiquitination
S303 Phosphorylation P24941 (CDK2)
T306 Phosphorylation P24941 (CDK2)
S308 Phosphorylation P24941 (CDK2)
S313 Phosphorylation
T315 Phosphorylation
Y316 Phosphorylation
K328 Ubiquitination
R343 Methylation
S344 Phosphorylation
T352 Phosphorylation
S505 Phosphorylation
K528 Acetylation

研究背景

功能:

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

细胞定位:

Cytoplasm. Cytoplasm>Cytoskeleton. Nucleus. Cell junction>Focal adhesion.
Note: Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Interacts with SYNPO2.

(Microbial infection) Interacts with human papillomavirus type 6/HPV6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18.

蛋白家族:

Belongs to the zyxin/ajuba family.

研究领域

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

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