产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
DAZ-interacting protein 3; E3 ubiquitin-protein ligase DZIP3; hRUL138; KIAA0675; RNA-binding ubiquitin ligase of 138 kDa;
抗原和靶标
Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
- Q86Y13 DZIP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNAINTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQAGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSLVYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIKTTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKYPGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLISLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPLLKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVFPAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRLGMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIEIEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQRKKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFYSLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQENQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHNLESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGHPSRQLPKI
翻译修饰 - Q86Y13 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| T242 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| Y392 | Phosphorylation | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| K635 | Ubiquitination | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| K663 | Acetylation | Uniprot | |
| K664 | Acetylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| K703 | Ubiquitination | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| K718 | Ubiquitination | Uniprot | |
| K738 | Ubiquitination | Uniprot | |
| K748 | Ubiquitination | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| K768 | Methylation | Uniprot | |
| K768 | Ubiquitination | Uniprot | |
| K786 | Ubiquitination | Uniprot | |
| K816 | Ubiquitination | Uniprot | |
| K821 | Ubiquitination | Uniprot | |
| K824 | Ubiquitination | Uniprot | |
| K830 | Ubiquitination | Uniprot | |
| K838 | Ubiquitination | Uniprot | |
| K846 | Ubiquitination | Uniprot | |
| K851 | Ubiquitination | Uniprot | |
| K883 | Ubiquitination | Uniprot | |
| K936 | Ubiquitination | Uniprot | |
| K1042 | Ubiquitination | Uniprot | |
| K1051 | Ubiquitination | Uniprot | |
| T1054 | Phosphorylation | Uniprot | |
| K1061 | Ubiquitination | Uniprot | |
| K1066 | Ubiquitination | Uniprot | |
| S1081 | Phosphorylation | Uniprot | |
| K1087 | Ubiquitination | Uniprot | |
| K1088 | Ubiquitination | Uniprot | |
| S1097 | Phosphorylation | Uniprot | |
| S1103 | Phosphorylation | Uniprot | |
| K1118 | Ubiquitination | Uniprot |
研究背景
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Cytoplasm.
Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
Interacts with DAZ proteins.
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