产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
BAF 170; BAF170; BRG1 associated factor 170; BRG1-associated factor 170; Chromatin remodeling complex BAF170 subunit; CRACC 2; CRACC2; Mammalian chromatin remodeling complex BRG1 associated factor 170; Rsc 8; Rsc8; SMARCC 2; Smarcc2; SMRC2_HUMAN; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI/SNF related matrix associated actin dependent regulator of chromatin c2; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI3 like protein;
抗原和靶标
- Q8TAQ2 SMRC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVNDDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETTGKDEDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQQTSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGNDEARVEGQATDEKKEPKEPREGGGAIEEEAKEKTSEAPKKDEEKGKEGDSEKESEKSDGDPIVDPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQQQQQPPPALPPGSQPIPPTGAAGPPAVHGLAVAPASVVPAPAGSGAPPGSLGPSEQIGQAGSTAGPQQQQPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPPPPPPPAPSIIPFGSLADSISINLPAPPNLHGHHHHLPFAPGTLPPPNLPVSMANPLHPNLPATTTMPSSLPLGPGLGSAAAQSPAIVAAVQGNLLPSASPLPDPGTPLPPDPTAPSPGTVTPVPPPQ
翻译修饰 - Q8TAQ2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K37 | Ubiquitination | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| C145 | S-Nitrosylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| Y179 | Phosphorylation | Uniprot | |
| T230 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| T276 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S286 | Phosphorylation | Uniprot | |
| Y296 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| T322 | Phosphorylation | Uniprot | |
| Y324 | Phosphorylation | Uniprot | |
| K326 | Acetylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| T400 | Phosphorylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| T548 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| S555 | Phosphorylation | Uniprot | |
| K564 | Ubiquitination | Uniprot | |
| K566 | Ubiquitination | Uniprot | |
| K568 | Ubiquitination | Uniprot | |
| T579 | Phosphorylation | Uniprot | |
| Y582 | Phosphorylation | Uniprot | |
| T583 | Phosphorylation | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| C635 | S-Nitrosylation | Uniprot | |
| K694 | Ubiquitination | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| K702 | Ubiquitination | Uniprot | |
| K704 | Sumoylation | Uniprot | |
| K704 | Ubiquitination | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| T726 | Phosphorylation | Uniprot | |
| K728 | Ubiquitination | Uniprot | |
| S738 | Phosphorylation | Uniprot | |
| S754 | Phosphorylation | Uniprot | |
| K769 | Acetylation | Uniprot | |
| K795 | Acetylation | Uniprot | |
| S806 | Phosphorylation | Uniprot | |
| S810 | Phosphorylation | Uniprot | |
| S813 | Phosphorylation | Uniprot | |
| K836 | Ubiquitination | Uniprot | |
| S841 | Phosphorylation | Uniprot | |
| K872 | Ubiquitination | Uniprot | |
| K874 | Ubiquitination | Uniprot | |
| K885 | Ubiquitination | Uniprot | |
| S886 | Phosphorylation | Uniprot | |
| K897 | Ubiquitination | Uniprot | |
| K898 | Ubiquitination | Uniprot | |
| K902 | Ubiquitination | Uniprot | |
| R931 | Methylation | Uniprot | |
| K940 | Ubiquitination | Uniprot | |
| S969 | Phosphorylation | Q13315 (ATM) , Q13535 (ATR) | Uniprot |
研究背景
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity).
Nucleus.
Ubiquitously expressed.
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. Interacts with SMARD1. Interacts with KDM6B (By similarity). Interaction with RCOR1. Interacts with DPF2. Interacts with ERCC6.
Belongs to the SMARCC family.
研究领域
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
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