| 产品: | MX1 抗体 |
| 货号: | DF6612 |
| 描述: | Rabbit polyclonal antibody to MX1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 76kDa; 76kD(Calculated). |
| 蛋白号: | P20591 |
| RRID: | AB_2838574 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6612, RRID:AB_2838574.
展开/折叠
Human interferon regulated resistance GTP binding protein MXA; IFI 78; IFI 78K; IFI-78K; IFI78; IFI78K; Interferon induced GTP binding protein Mx1; Interferon induced protein p78; Interferon inducible protein p78; Interferon regulated resistance GTP binding protein; Interferon regulated resistance GTP binding protein MxA; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; MX 1; MX; MX dynamin-like GTPase 1; MX1; MX1_HUMAN; MxA; Myxoma resistance protein 1; Myxovirus (influenza virus) resistance 1 interferon inducible; Myxovirus (influenza virus) resistance 1 interferon inducible protein p78; Myxovirus (influenza) resistance 1 homolog of murine; Myxovirus resistance 1, mouse, homolog of; Myxovirus resistance protein 1; N-terminally processed;
抗原和靶标
- P20591 MX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG
翻译修饰 - P20591 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| Y126 | Phosphorylation | Uniprot | |
| Y129 | Phosphorylation | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| Y308 | Phosphorylation | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K432 | Ubiquitination | Uniprot | |
| K435 | Ubiquitination | Uniprot | |
| Y451 | Phosphorylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K490 | Ubiquitination | Uniprot | |
| K505 | Ubiquitination | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| K631 | Ubiquitination | Uniprot |
研究背景
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
ISGylated.
Cytoplasm. Endoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Perinuclear region.
Note: Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845).
Cytoplasm. Nucleus.
Note: Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636).
Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with DDX39A and DDX39B. Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with THOV P5 protein. The GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N.
The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
The middle domain mediates self-assembly and oligomerization.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
研究领域
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
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