BMPR2 Antibody - #BF0342
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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# BF0342, RRID:AB_2833896.
展开/折叠
BMP type II receptor; BMP type-2 receptor; BMPR 2; BMPR 3; BMPR II; BMPR-2; BMPR-II; Bmpr2; BMPR2_HUMAN; BMPR3; BMPRII; BMR 2; BMR2; Bone morphogenetic protein receptor type 2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; Bone morphogenic protein receptor type II serine threonine kinase; BRK 3; BRK3; PPH 1; PPH1; Serine threonine kinase type II activin receptor like kinase; T ALK; TALK; Type II activin receptor like kinase;
抗原和靶标
Purified recombinant fragment of human BMPR2 expressed in E. Coli.
- Q13873 BMPR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL
翻译修饰 - Q13873 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K219 | Acetylation | Uniprot | |
Y247 | Phosphorylation | Uniprot | |
Y314 | Phosphorylation | Uniprot | |
S336 | Phosphorylation | Uniprot | |
S355 | Phosphorylation | Uniprot | |
T359 | Phosphorylation | Uniprot | |
S375 | Phosphorylation | Uniprot | |
T379 | Phosphorylation | Uniprot | |
S513 | Phosphorylation | Uniprot | |
S515 | Phosphorylation | Uniprot | |
K539 | Ubiquitination | Uniprot | |
Y546 | Phosphorylation | Uniprot | |
S547 | Phosphorylation | Uniprot | |
S550 | Phosphorylation | Uniprot | |
Y551 | Phosphorylation | Uniprot | |
K564 | Ubiquitination | Uniprot | |
S574 | Phosphorylation | Uniprot | |
T575 | Phosphorylation | Uniprot | |
S586 | Phosphorylation | Uniprot | |
Y589 | Phosphorylation | Uniprot | |
S680 | Phosphorylation | Uniprot | |
S681 | Phosphorylation | Uniprot | |
Y708 | Phosphorylation | Uniprot | |
S757 | Phosphorylation | Uniprot | |
K763 | Ubiquitination | Uniprot | |
T803 | Phosphorylation | Uniprot | |
T805 | Phosphorylation | Uniprot | |
Y825 | Phosphorylation | Uniprot | |
S862 | Phosphorylation | Uniprot | |
S863 | Phosphorylation | Uniprot | |
T977 | Phosphorylation | Uniprot | |
Y979 | Phosphorylation | Uniprot | |
S980 | Phosphorylation | Uniprot |
研究背景
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Cell membrane>Single-pass type I membrane protein.
Highly expressed in heart and liver.
Interacts with GDF5.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Organismal Systems > Development > Axon guidance. (View pathway)
文献引用
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