CDK5 Antibody - #BF0121

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产品: CDK5 抗体
货号: BF0121
描述: Mouse monoclonal antibody to CDK5
应用: WB IHC IF/ICC ELISA FACS
文献验证: IF/ICC
反应: Human, Rat, Monkey
蛋白号: Q00535
RRID: AB_2833913

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   规格 价格 库存
 50ul RMB¥ 1800 现货
 100ul RMB¥ 2800 现货

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MSDS
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WB Handbook
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IF/ICC Protocol

产品描述

来源:
Mouse
应用:
ELISA 1:10000, WB 1:500-1:2000, IHC 1:200-1:1000, IF/ICC 1:200-1:1000, FCM 1:200-1:400
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat, Monkey
克隆:
Monoclonal [AFB1889]
特异性:
CDK5 antibody detects endogenous levels of total CDK5.
RRID:
AB_2833913
引用格式: Affinity Biosciences Cat# BF0121, RRID:AB_2833913.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Cdk 5; Cdk5; CDK5_HUMAN; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Cyclin-dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit;

抗原和靶标

免疫原:

Purified recombinant fragment of human CDK5 expressed in E. Coli.

基因/基因ID:
CDK5(1020)
描述:
CDK5 is a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer s pateints show elevated CDK5 activity.

研究领域

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Substance dependence > Cocaine addiction.

· Organismal Systems > Development > Axon guidance.   (View pathway)

文献引用

1). CDK5 Regulates PD-L1 Expression and Cell Maturation in Dendritic Cells of CRSwNP. INFLAMMATION, 2019 (PubMed: 30187339) [IF=4.5]

Application: IF/ICC    Species: human    Sample: nasal mucosal

Fig. 2. |The expression of CDK5 and PD-L1 in DCs of CRSwNPs. a Expression patterns of CDK5 and PD-L1 in nasal mucosal tissue of controlled,EosCRSwNP, and non-EosCRSwNP (×400 magnification; CDK5 stained in green; PD-L1 stained in red; nucleus stained in blue; scale bar = 100 μm).
2). MiR-142-5p directly targets cyclin-dependent kinase 5-mediated upregulation of the inflammatory process in acquired middle ear cholesteatoma. Molecular Immunology, 2022 (PubMed: 34875451) [IF=3.2]

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