| 产品: | OGR1/GPR68 抗体 |
| 货号: | AF0723 |
| 描述: | Rabbit polyclonal antibody to OGR1/GPR68 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 40~70 kD; 41kD(Calculated). |
| 蛋白号: | Q15743 |
| RRID: | AB_2834264 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0723, RRID:AB_2834264.
展开/折叠
G protein coupled receptor 68; G-protein coupled receptor 68; GPR 12A; GPR 68; GPR12A; Gpr68; MGC111379; MGC156983; OGR 1; OGR-1; OGR1; OGR1_HUMAN; Ovarian cancer G protein coupled receptor 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor;
抗原和靶标
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
- Q15743 OGR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15743 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y187 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| Y244 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot |
研究背景
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).
Cell membrane>Multi-pass membrane protein.
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
Belongs to the G-protein coupled receptor 1 family.
限制条款
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