产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0508, RRID:AB_2834267.
展开/折叠
CFL1; HGNC11644; Protein YL-1; Swc2; TCFL1; Transcription factor like 1 (YL1); Transcription Factor Like 1; Transcription factor-like 1; Vacuolar protein sorting 72 (yeast); Vacuolar protein sorting 72 homolog (S. cerevisiae); Vacuolar protein sorting associated protein 72 homolog; Vacuolar protein sorting-associated protein 72 homolog; VPS72; VPS72_HUMAN; YL-1; YL1;
抗原和靶标
- Q15906 VPS72_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15906 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R7 | Methylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| T86 | Phosphorylation | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| T168 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K197 | Acetylation | Uniprot | |
| K198 | Acetylation | Uniprot | |
| K203 | Acetylation | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| Y326 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot |
研究背景
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Nucleus.
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ. Interacts (via N-terminal domain) with heterodimer H2BC11 and H2AZ1.
Belongs to the VPS72/YL1 family.
限制条款
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