| 产品: | ATPBD3 抗体 |
| 货号: | AF0721 |
| 描述: | Rabbit polyclonal antibody to ATPBD3 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine |
| 分子量: | 36~43kDa; 36kD(Calculated). |
| 蛋白号: | Q7Z7A3 |
| RRID: | AB_2834295 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0721, RRID:AB_2834295.
展开/折叠
ATP binding domain 3; ATP-binding domain-containing protein 3; Cancer associated protein; Cancer-associated gene protein; ctu1; CTU1_HUMAN; Cytoplasmic tRNA 2-thiolation protein 1; Cytoplasmic tRNA adenylyltransferase 1; Cytosolic thiouridylase subunit 1 homolog; NCS6;
抗原和靶标
- Q7Z7A3 CTU1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLAGRLLPPGAVVAVGASGGKDSTVLAHVLRALAPRLGISLQLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARRVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQKEVVLYAHFRRLDYFSEECVYAPEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALAPAARPPRPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPGDPARPPASKAVPTF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q7Z7A3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S81 | Phosphorylation | Uniprot | |
| Y94 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| R194 | Methylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| T329 | Phosphorylation | Uniprot | |
| T332 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot |
研究背景
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Cytoplasm.
Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Sulfur relay system. (View pathway)
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