产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0475, RRID:AB_2834335.
展开/折叠
AUGN_HUMAN; Augurin; C2orf40; Esophageal cancer-related gene 4 protein;
抗原和靶标
A synthesized peptide derived from human ECRG4, corresponding to a region within C-terminal amino acids.
Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).
- Q9H1Z8 AUGN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASPARPAVLALTGLALLLLLCWGPGGISGNKLKLMLQKREAPVPTKTKVAVDENKAKEFLGSLKRQKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQRHYDEDSAIGPRSPYGFRHGASVNYDDY
翻译修饰 - Q9H1Z8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K48 | Methylation | Uniprot | |
| K50 | Methylation | Uniprot | |
| K57 | Methylation | Uniprot |
研究背景
Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity).
Secreted. Cytoplasm. Apical cell membrane.
Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).
Belongs to the augurin family.
限制条款
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