CDK13 Antibody - #DF10026

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产品: CDK13 抗体
货号: DF10026
描述: Rabbit polyclonal antibody to CDK13
应用: WB IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 165 kDa; 165kD(Calculated).
蛋白号: Q14004
RRID: AB_2840606

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(89%), Xenopus(100%)
克隆:
Polyclonal
特异性:
CDK13 Antibody detects endogenous levels of total CDK13.
RRID:
AB_2840606
引用格式: Affinity Biosciences Cat# DF10026, RRID:AB_2840606.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CDC2 related protein kinase 5; CDC2-related protein kinase 5; CDC2L; CDK13; CDK13_HUMAN; cell division controller cholinesterase related; cell division cycle 2 like 5 (cholinesterase related cell division controller); cell division cycle 2 like 5; Cell division cycle 2 like protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; CHED; Cholinesterase related cell division controller; Cholinesterase-related cell division controller; cyclin dependent kinase 13; Cyclin-dependent kinase 13; hCDK13;

抗原和靶标

免疫原:
Uniprot:

Q14004(CDK13_HUMAN) >>Visit HPA database.

基因/基因ID:
CDK13(8621)
表达:
Q14004 CDK13_HUMAN:

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

序列:
MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Chicken
89
Zebrafish
78
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q14004 作为底物

Site PTM Type Enzyme
S3 Phosphorylation
S4 Phosphorylation
S5 Phosphorylation
S135 Phosphorylation
S136 Phosphorylation
T141 Phosphorylation
S151 Phosphorylation
S204 Phosphorylation
S205 Phosphorylation
S209 Phosphorylation
S236 Phosphorylation
S238 Phosphorylation
S260 Phosphorylation
S262 Phosphorylation
S268 Phosphorylation
S276 Phosphorylation
S281 Phosphorylation
S285 Phosphorylation
S291 Phosphorylation
S315 Phosphorylation
S317 Phosphorylation
S325 Phosphorylation
S328 Phosphorylation
S337 Phosphorylation
S340 Phosphorylation
S342 Phosphorylation
S348 Phosphorylation
S349 Phosphorylation
Y351 Phosphorylation
S352 Phosphorylation
S358 Phosphorylation
S360 Phosphorylation
Y362 Phosphorylation
S363 Phosphorylation
S367 Phosphorylation
S369 Phosphorylation
S371 Phosphorylation
S374 Phosphorylation
S375 Phosphorylation
Y376 Phosphorylation
S383 Phosphorylation
S385 Phosphorylation
S391 Phosphorylation
S395 Phosphorylation
S397 Phosphorylation
Y399 Phosphorylation
S400 Phosphorylation
S409 Phosphorylation
S411 Phosphorylation
S413 Phosphorylation
Y415 Phosphorylation
S431 Phosphorylation
S433 Phosphorylation
S436 Phosphorylation
S437 Phosphorylation O14757 (CHEK1)
S439 Phosphorylation
S441 Phosphorylation
T442 Phosphorylation
S490 Phosphorylation
S493 Phosphorylation
T494 Phosphorylation
T496 Phosphorylation
T500 Phosphorylation
T502 Phosphorylation
S507 Phosphorylation
K519 Sumoylation
S525 Phosphorylation
S527 Phosphorylation
S528 Phosphorylation
T531 Phosphorylation
T539 Phosphorylation
K556 Acetylation
K566 Acetylation
K583 Acetylation
K585 Acetylation
T588 Phosphorylation
S590 Phosphorylation
S624 Phosphorylation
S630 Phosphorylation
K632 Ubiquitination
S662 Phosphorylation
S664 Phosphorylation
Y687 Phosphorylation
K699 Ubiquitination
Y716 Phosphorylation
K742 Ubiquitination
T748 Phosphorylation
K774 Ubiquitination
K781 Ubiquitination
Y827 Phosphorylation
S864 Phosphorylation
S867 Phosphorylation
T871 Phosphorylation
K951 Acetylation
S1022 Phosphorylation
T1034 Phosphorylation
K1045 Ubiquitination
S1048 Phosphorylation
S1054 Phosphorylation
T1056 Phosphorylation
T1058 Phosphorylation
S1066 Phosphorylation
T1143 Phosphorylation
S1146 Phosphorylation
T1147 Phosphorylation
S1153 Phosphorylation
S1163 Phosphorylation
K1199 Ubiquitination
S1225 Phosphorylation
T1226 Phosphorylation
S1229 Phosphorylation
T1246 Phosphorylation
Y1277 Phosphorylation
K1316 Ubiquitination
S1342 Phosphorylation
S1346 Phosphorylation

翻译修饰 - Q14004 作为激酶

Substrate Site Source
P24928 (POLR2A) S1616 Uniprot
P24928 (POLR2A) S1619 Uniprot

研究背景

功能:

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

细胞定位:

Nucleus speckle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

亚基结构:

Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK. Interacts with C1QBP.

(Microbial infection) Interacts with HIV-1 Tat.

蛋白家族:

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

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