| 产品: | CYFIP1 抗体 |
| 货号: | DF10059 |
| 描述: | Rabbit polyclonal antibody to CYFIP1 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 145 kDa; 145kD(Calculated). |
| 蛋白号: | Q7L576 |
| RRID: | AB_2840639 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF10059, RRID:AB_2840639.
展开/折叠
CY; CYFIP 1; CYFIP1; CYFP1_HUMAN; Cytoplasmic FMR1 interacting protein 1; Cytoplasmic FMR1-interacting protein 1; FLJ45151; KIAA0068; p140sra 1; p140sra-1; P140SRA1; Selective hybridizing clone; SHYC; Specifically Rac1 associated protein 1; Specifically Rac1-associated protein 1; SRA 1; Sra-1; SRA1;
抗原和靶标
- Q7L576 CYFP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q7L576 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K97 | Ubiquitination | Uniprot | |
| Y108 | Phosphorylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K182 | Acetylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K189 | Acetylation | Uniprot | |
| K197 | Acetylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| Y254 | Phosphorylation | Uniprot | |
| T256 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| Y298 | Phosphorylation | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| T420 | Phosphorylation | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| K516 | Ubiquitination | Uniprot | |
| K540 | Ubiquitination | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| Y560 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| S574 | Phosphorylation | Uniprot | |
| T579 | Phosphorylation | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| K715 | Ubiquitination | Uniprot | |
| K725 | Ubiquitination | Uniprot | |
| K751 | Ubiquitination | Uniprot | |
| T769 | Phosphorylation | Uniprot | |
| K778 | Ubiquitination | Uniprot | |
| S872 | Phosphorylation | Uniprot | |
| K879 | Ubiquitination | Uniprot | |
| Y887 | Phosphorylation | Uniprot | |
| S900 | Phosphorylation | Uniprot | |
| K935 | Ubiquitination | Uniprot | |
| Y967 | Phosphorylation | Uniprot | |
| Y986 | Phosphorylation | Uniprot | |
| K1038 | Ubiquitination | Uniprot | |
| S1052 | Phosphorylation | Uniprot | |
| K1053 | Ubiquitination | Uniprot | |
| Y1054 | Phosphorylation | Uniprot | |
| T1068 | Phosphorylation | Uniprot | |
| K1083 | Ubiquitination | Uniprot | |
| K1188 | Ubiquitination | Uniprot | |
| K1197 | Acetylation | Uniprot | |
| K1197 | Ubiquitination | Uniprot | |
| K1210 | Ubiquitination | Uniprot | |
| K1227 | Ubiquitination | Uniprot | |
| T1234 | Phosphorylation | Uniprot | |
| S1253 | Phosphorylation | Uniprot |
研究背景
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers.
Cytoplasm. Cytoplasm>Perinuclear region. Cell projection>Lamellipodium. Cell projection>Ruffle. Cell junction>Synapse>Synaptosome.
Note: Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity).
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with FMR1 but does not bind to related proteins FXR1 or FXR2. Interaction with EIF4E stimulates FMR1 binding. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2. Interacts with the active GTP-bound form of RAC1. Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth. Interacts with NYAP1, NYAP2 and MYO16. Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (By similarity).
Belongs to the CYFIP family.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Genetic Information Processing > Translation > RNA transport.
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