| 产品: | IL28RA 抗体 |
| 货号: | DF10108 |
| 描述: | Rabbit polyclonal antibody to IL28RA |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Rabbit, Dog |
| 分子量: | 58 kDa; 58kD(Calculated). |
| 蛋白号: | Q8IU57 |
| RRID: | AB_2840688 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF10108, RRID:AB_2840688.
展开/折叠
Class II cytokine receptor CRF2/12; CRF2-12; CRF2/12; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; IFN lambda R1; IFN-lambda receptor 1; IFNLR; IFNLR1; IL-28 receptor subunit alpha; il-28r1; IL28R alpha; IL28RA; Interferon lambda receptor; Interferon lambda receptor 1; interleukin 28 alpha receptor; interleukin 28 receptor A; Interleukin 28 receptor alpha chain; interleukin 28 receptor, alpha (interferon, lambda receptor); Interleukin 28 receptor, alpha; interleukin or cytokine receptor 2; Interleukin-28 receptor subunit alpha; LICR2; Likely interleukin or cytokine receptor 2;
抗原和靶标
- Q8IU57 INLR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8IU57 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N29 | N-Glycosylation | Uniprot | |
| N36 | N-Glycosylation | Uniprot | |
| N142 | N-Glycosylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| Y209 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| Y517 | Phosphorylation | Uniprot |
研究背景
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Membrane>Single-pass type I membrane protein.
Widely expressed.
Heterodimer with IL10RB.
Belongs to the type II cytokine receptor family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
限制条款
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