| 产品: | IL31R 抗体 |
| 货号: | DF10114 |
| 描述: | Rabbit polyclonal antibody to IL31R |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Bovine, Sheep, Dog |
| 分子量: | 83 kDa; 83kD(Calculated). |
| 蛋白号: | Q8NI17 |
| RRID: | AB_2840694 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF10114, RRID:AB_2840694.
展开/折叠
Class I cytokine receptor; CRL 3; CRL; CRL3; Cytokine receptor like 3; Cytokine receptor-like 3; GLM R; GLM-R; GLMR; Gp130 like monocyte receptor; GP130 like receptor; Gp130-like monocyte receptor; Gp130-like receptor; GPL; HGLM R; HGLM-R; HGLMR; IL 31 receptor subunit alpha; IL 31R subunit alpha; IL 31RA; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; IL31 receptor subunit alpha; IL31R subunit alpha; IL31R_HUMAN; IL31RA; Interleukin 31 receptor A; interleukin 31 receptor subunit alpha; Interleukin-31 receptor subunit alpha; MGC125346; PLCA 2; PLCA2; PRO21384; Soluble type I cytokine receptor CRL3; ZcytoR17;
抗原和靶标
Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).
- Q8NI17 IL31R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMWTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8NI17 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T122 | Phosphorylation | Uniprot | |
| Y460 | Phosphorylation | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| Y708 | Phosphorylation | Uniprot |
研究背景
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).
N-glycosylated.
Cell membrane>Single-pass type I membrane protein. Cell junction>Synapse>Presynaptic cell membrane. Cell projection>Axon.
Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts. Detected in all of the myelomonocytic lineage. Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients.
Heterodimer with OSMR. Interacts with JAK1 and STAT3.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
限制条款
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