| 产品: | CCNB3 抗体 |
| 货号: | DF10120 |
| 描述: | Rabbit polyclonal antibody to CCNB3 |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 158 kDa; 158kD(Calculated). |
| 蛋白号: | Q8WWL7 |
| RRID: | AB_2840700 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF10120, RRID:AB_2840700.
展开/折叠
CCNB 3; CYCB3; G2/mitotic specific cyclin B3;
抗原和靶标
Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.
- Q8WWL7 CCNB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKRSAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL
翻译修饰 - Q8WWL7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K87 | Acetylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| K364 | Acetylation | Uniprot | |
| K416 | Acetylation | Uniprot | |
| T497 | Phosphorylation | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| Y618 | Phosphorylation | Uniprot | |
| K633 | Acetylation | Uniprot | |
| K643 | Acetylation | Uniprot | |
| K656 | Acetylation | Uniprot | |
| S753 | Phosphorylation | Uniprot | |
| T754 | Phosphorylation | Uniprot | |
| S954 | Phosphorylation | Uniprot | |
| S996 | Phosphorylation | Uniprot | |
| S1000 | Phosphorylation | Uniprot | |
| T1002 | Phosphorylation | Uniprot | |
| T1038 | Phosphorylation | Uniprot | |
| S1089 | Phosphorylation | Uniprot | |
| S1120 | Phosphorylation | Uniprot | |
| S1174 | Phosphorylation | Uniprot | |
| T1178 | Phosphorylation | Uniprot | |
| Y1319 | Phosphorylation | Uniprot | |
| S1331 | Phosphorylation | Uniprot | |
| S1333 | Phosphorylation | Uniprot |
研究背景
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.
Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.
Nucleus.
Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.
Interacts with CDK2 kinase.
The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Belongs to the cyclin family. Cyclin AB subfamily.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
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