AKAP2 Antibody - #AF0651

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产品: AKAP2 抗体
货号: AF0651
描述: Rabbit polyclonal antibody to AKAP2
应用: WB IF/ICC
反应: Human
预测: Pig
分子量: 96kDa; 95kD(Calculated).
蛋白号: Q9Y2D5
RRID: AB_2834353

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(82%)
克隆:
Polyclonal
特异性:
AKAP2 Antibody detects endogenous levels of total AKAP2.
RRID:
AB_2834353
引用格式: Affinity Biosciences Cat# AF0651, RRID:AB_2834353.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A kinase (PRKA) anchor protein 2; A kinase anchor protein 2; AKAP 2; AKAP KL; AKAPKL; KIAA0920; PALM 2; PALM2; PRKA 2; PRKA2; Protein kinase A anchoring protein 2; Protein kinase A2;

抗原和靶标

免疫原:
Uniprot:

Q9Y2D5(AKAP2_HUMAN) >>Visit HPA database.

基因/基因ID:
AKAP2(11217)
描述:
AKAP2 Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. 5 isoforms of the human protein are produced by alternative splicing.
序列:
MEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSVLEATRVNRRKSALALRWEAGIYANQEEEDNE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
82
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9Y2D5 作为底物

Site PTM Type Enzyme
S27 Phosphorylation
Y30 Phosphorylation
S31 Phosphorylation
S44 Phosphorylation
S91 Phosphorylation
S118 Phosphorylation
S121 Phosphorylation
S135 Phosphorylation
S137 Phosphorylation
S146 Phosphorylation
S152 Phosphorylation
S154 Phosphorylation
S155 Phosphorylation
T157 Phosphorylation
S158 Phosphorylation
S159 Phosphorylation
T169 Phosphorylation
T172 Phosphorylation
K174 Sumoylation
Y204 Phosphorylation
K208 Ubiquitination
S212 Phosphorylation
K220 Ubiquitination
S324 Phosphorylation
Y356 Phosphorylation
S361 Phosphorylation
S364 Phosphorylation
S375 Phosphorylation
S383 Phosphorylation
S393 Phosphorylation
T399 Phosphorylation
S401 Phosphorylation
S405 Phosphorylation
T409 Phosphorylation
S411 Phosphorylation
Y418 Phosphorylation
S419 Phosphorylation
S422 Phosphorylation
K429 Ubiquitination
K448 Ubiquitination
S461 Phosphorylation
S465 Phosphorylation
T467 Phosphorylation
S473 Phosphorylation
S479 Phosphorylation
S501 Phosphorylation
S517 Phosphorylation
S522 Phosphorylation
T526 Phosphorylation
Y550 Phosphorylation
Y568 Phosphorylation
S622 Phosphorylation
S630 Phosphorylation
S631 Phosphorylation
Y680 Phosphorylation
K683 Ubiquitination
Y684 Phosphorylation
K710 Ubiquitination
T718 Phosphorylation
S720 Phosphorylation
S745 Phosphorylation
T746 Phosphorylation
S748 Phosphorylation
S756 Phosphorylation
Y763 Phosphorylation
T765 Phosphorylation
S778 Phosphorylation
T780 Phosphorylation
T781 Phosphorylation
S785 Phosphorylation
T798 Phosphorylation
Y812 Phosphorylation
T814 Phosphorylation
S817 Phosphorylation
S839 Phosphorylation
Y850 Phosphorylation

研究背景

功能:

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).

蛋白家族:

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

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