| 产品: | AKAP2 抗体 |
| 货号: | AF0651 |
| 描述: | Rabbit polyclonal antibody to AKAP2 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig |
| 分子量: | 96kDa; 95kD(Calculated). |
| 蛋白号: | Q9Y2D5 |
| RRID: | AB_2834353 |
产品描述
来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
反应:
Human
预测:
Pig(82%)
克隆:
Polyclonal
特异性:
AKAP2 Antibody detects endogenous levels of total AKAP2.
RRID:
AB_2834353
引用格式: Affinity Biosciences Cat# AF0651, RRID:AB_2834353.
引用格式: Affinity Biosciences Cat# AF0651, RRID:AB_2834353.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:
展开/折叠
A kinase (PRKA) anchor protein 2; A kinase anchor protein 2; AKAP 2; AKAP KL; AKAPKL; KIAA0920; PALM 2; PALM2; PRKA 2; PRKA2; Protein kinase A anchoring protein 2; Protein kinase A2;
抗原和靶标
免疫原:
Uniprot:
基因/基因ID:
描述:
AKAP2 Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. 5 isoforms of the human protein are produced by alternative splicing.
序列:
- Q9Y2D5 AKAP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSVLEATRVNRRKSALALRWEAGIYANQEEEDNE
种属预测
种属预测:
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
Species
Results
Score
Pig
82
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y2D5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S27 | Phosphorylation | Uniprot | |
| Y30 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| T172 | Phosphorylation | Uniprot | |
| K174 | Sumoylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| T399 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| T409 | Phosphorylation | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| Y418 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| T467 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Uniprot | |
| T526 | Phosphorylation | Uniprot | |
| Y550 | Phosphorylation | Uniprot | |
| Y568 | Phosphorylation | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| S630 | Phosphorylation | Uniprot | |
| S631 | Phosphorylation | Uniprot | |
| Y680 | Phosphorylation | Uniprot | |
| K683 | Ubiquitination | Uniprot | |
| Y684 | Phosphorylation | Uniprot | |
| K710 | Ubiquitination | Uniprot | |
| T718 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S745 | Phosphorylation | Uniprot | |
| T746 | Phosphorylation | Uniprot | |
| S748 | Phosphorylation | Uniprot | |
| S756 | Phosphorylation | Uniprot | |
| Y763 | Phosphorylation | Uniprot | |
| T765 | Phosphorylation | Uniprot | |
| S778 | Phosphorylation | Uniprot | |
| T780 | Phosphorylation | Uniprot | |
| T781 | Phosphorylation | Uniprot | |
| S785 | Phosphorylation | Uniprot | |
| T798 | Phosphorylation | Uniprot | |
| Y812 | Phosphorylation | Uniprot | |
| T814 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| S839 | Phosphorylation | Uniprot | |
| Y850 | Phosphorylation | Uniprot |
研究背景
功能:
Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).
蛋白家族:
The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
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