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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF10170, RRID:AB_2840749.
展开/折叠
AI853584; Blood group--MN locus; CD_antigen=CD235a; CD235a; GLPA_HUMAN; Glycophorin A (MNS blood group); Glycophorin A; Glycophorin A, included; Glycophorin-A; GlycophorinA; GPA; GPErik; GpMiIII; GPSAT; GYPA; GYPA, included; HGpMiIII; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C); MN; MN sialoglycoprotein; MNS; PAS-2; PAS2; Sialoglycoprotein alpha;
抗原和靶标
- P02724 GLPA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYGKIIFVLLLSEIVSISASSTTGVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ
翻译修饰 - P02724 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | O-Glycosylation | Uniprot | |
| T22 | O-Glycosylation | Uniprot | |
| T23 | O-Glycosylation | Uniprot | |
| T29 | O-Glycosylation | Uniprot | |
| S30 | O-Glycosylation | Uniprot | |
| T31 | O-Glycosylation | Uniprot | |
| S32 | O-Glycosylation | Uniprot | |
| T36 | O-Glycosylation | Uniprot | |
| S38 | O-Glycosylation | Uniprot | |
| S41 | O-Glycosylation | Uniprot | |
| T44 | O-Glycosylation | Uniprot | |
| N45 | N-Glycosylation | Uniprot | |
| T52 | O-Glycosylation | Uniprot | |
| T56 | O-Glycosylation | Uniprot | |
| S63 | O-Glycosylation | Uniprot | |
| S66 | O-Glycosylation | Uniprot | |
| T69 | O-Glycosylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot |
研究背景
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
Cell membrane>Single-pass type I membrane protein.
Note: Appears to be colocalized with SLC4A1.
Homodimer.
(Microbial infection) Interacts with Streptococcus gordonii hsa protein.
Belongs to the glycophorin A family.
研究领域
· Human Diseases > Infectious diseases: Parasitic > Malaria.
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
文献引用
Application: WB Species: mouse Sample: erythrocyte
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