HTR3C Antibody - #DF10196

(2)  
产品: HTR3C 抗体
货号: DF10196
描述: Rabbit polyclonal antibody to HTR3C
应用: WB IF/ICC
反应: Human, Rat
分子量: 50 kDa; 50kD(Calculated).
蛋白号: Q8WXA8
RRID: AB_2840775

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 100ul RMB¥ 2300 现货
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
克隆:
Polyclonal
特异性:
HTR3C Antibody detects endogenous levels of total HTR3C.
RRID:
AB_2840775
引用格式: Affinity Biosciences Cat# DF10196, RRID:AB_2840775.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

5 HT3 C; 5 HT3C; 5 hydroxytryptamine (serotonin) receptor 3, family member C; 5 hydroxytryptamine (serotonin) receptor 3C ionotropic; 5 hydroxytryptamine receptor 3 subunit C; 5 hydroxytryptamine receptor 3C; Serotonin receptor 3C;

抗原和靶标

免疫原:
Uniprot:

Q8WXA8(5HT3C_HUMAN) >>Visit HPA database.

基因/基因ID:
HTR3C(170572)
表达:
Q8WXA8 5HT3C_HUMAN:

Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.

序列:
MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT

翻译修饰 - Q8WXA8 作为底物

Site PTM Type Enzyme
Y234 Phosphorylation
T398 Phosphorylation
S404 Phosphorylation
T407 Phosphorylation

研究背景

功能:

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

细胞定位:

Cell membrane>Multi-pass membrane protein.
Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.

亚基结构:

Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

蛋白家族:

Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.

研究领域

· Organismal Systems > Nervous system > Serotonergic synapse.

· Organismal Systems > Sensory system > Taste transduction.

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