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| 产品: | DRD3 抗体 |
| 货号: | DF10212 |
| 描述: | Rabbit polyclonal antibody to DRD3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 44 kDa; 44kD(Calculated). |
| 蛋白号: | P35462 |
| RRID: | AB_2815010 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF10212, RRID:AB_2815010.
展开/折叠
3dopamine receptor; D; D(3) dopamine receptor; Dopamine D3 receptor; Dopamine receptor D3; DRD3; DRD3_HUMAN; ETM1; FET1;
抗原和靶标
- P35462 DRD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P35462 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T142 | Phosphorylation | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S233 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| T289 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot |
研究背景
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
Palmitoylated.
Cell membrane>Multi-pass membrane protein.
Note: Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
Brain.
Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Nervous system > Dopaminergic synapse.
文献引用
Application: WB Species: Sample: BMDMs
限制条款
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