产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0177, RRID:AB_2833370.
展开/折叠
CG beta; CG-beta; CGB; CGB3; CGB5; CGB7; CGB8; CGHB_HUMAN; Choriogonadotropin subunit beta; Chorionic gonadotrophin chain beta; Chorionic gonadotropin beta 3 subunit; Chorionic gonadotropin beta polypeptide; Chorionic gonadotropin beta subunit; hCGB;
抗原和靶标
- P0DN86 CGB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ
翻译修饰 - P0DN86 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| T117 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S141 | O-Glycosylation | Uniprot | |
| S147 | O-Glycosylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| S152 | O-Glycosylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| S158 | O-Glycosylation | Uniprot |
研究背景
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Secreted.
High expression in the placenta throughout pregnancy.
Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
Belongs to the glycoprotein hormones subunit beta family.
限制条款
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