产品: hCG beta 抗体
货号: AF0177
描述: Rabbit polyclonal antibody to hCG beta
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
分子量: 20kDa; 18kD(Calculated).
蛋白号: P0DN86
RRID: AB_2833370

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
hCG beta Antibody detects endogenous levels of total hCG beta.
RRID:
AB_2833370
引用格式: Affinity Biosciences Cat# AF0177, RRID:AB_2833370.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CG beta; CG-beta; CGB; CGB3; CGB5; CGB7; CGB8; CGHB_HUMAN; Choriogonadotropin subunit beta; Chorionic gonadotrophin chain beta; Chorionic gonadotropin beta 3 subunit; Chorionic gonadotropin beta polypeptide; Chorionic gonadotropin beta subunit; hCGB;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P0DN86 CGB3_HUMAN:

High expression in the placenta throughout pregnancy.

描述:
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
序列:
MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ

翻译修饰 - P0DN86 作为底物

Site PTM Type Enzyme
S14 Phosphorylation
Y79 Phosphorylation
T117 Phosphorylation P17612 (PRKACA)
S141 O-Glycosylation
S147 O-Glycosylation
S147 Phosphorylation
S150 Phosphorylation
S152 O-Glycosylation
S152 Phosphorylation
S158 O-Glycosylation

研究背景

功能:

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

High expression in the placenta throughout pregnancy.

亚基结构:

Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.

蛋白家族:

Belongs to the glycoprotein hormones subunit beta family.

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