产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0626, RRID:AB_2834374.
展开/折叠
COX 17; COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); COX17 cytochrome c oxidase assembly homolog; COX17 homolog cytochrome c oxidase assembly protein; COX17_HUMAN; cytochrome c oxidase assembly protein cox17 homolog; Cytochrome c oxidase copper chaperone; Human homolog of yeast mitochondrial copper recruitment; MGC104397; MGC117386; OTTHUMP00000215284; OTTHUMP00000215285;
抗原和靶标
- Q14061 COX17_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14061 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S7 | Phosphorylation | Uniprot | |
S14 | Phosphorylation | Uniprot | |
K17 | Acetylation | Uniprot | |
K18 | Acetylation | Uniprot | |
K21 | Acetylation | Uniprot | |
K30 | Acetylation | Uniprot | |
K31 | Acetylation | Uniprot | |
K62 | Ubiquitination | Uniprot |
研究背景
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Mitochondrion intermembrane space. Cytoplasm.
Ubiquitous.
Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.
Belongs to the COX17 family.
研究领域
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
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