产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0578, RRID:AB_2834375.
展开/折叠
COX19 cytochrome c oxidase assembly homolog (S. cerevisiae); hCOX19;
抗原和靶标
- Q49B96 COX19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTAMNFGTKSFQPRPPDKGSFPLDHLGECKSFKEKFMKCLHNNNFENALCRKESKEYLECRMERKLMLQEPLEKLGFGDLTSGKSEAKK
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q49B96 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S2 | Acetylation | Uniprot | |
S55 | Phosphorylation | Uniprot | |
Y58 | Phosphorylation | Uniprot | |
K85 | Ubiquitination | Uniprot |
研究背景
Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity).
Cytoplasm>Cytosol. Mitochondrion intermembrane space. Mitochondrion.
Note: Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated.
Ubiquitously expressed. Highly expressed in skeletal muscle.
Interacts with CHCHD4/MIA40 forming transient intermolecular disulfide bridges.
Belongs to the COX19 family.
限制条款
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