| 产品: | MSI1 抗体 |
| 货号: | DF2971 |
| 描述: | Rabbit polyclonal antibody to MSI1 |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 39kDa; 39kD(Calculated). |
| 蛋白号: | O43347 |
| RRID: | AB_2840951 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2971, RRID:AB_2840951.
展开/折叠
Msi 1; Msi1; MSI1H_HUMAN; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1;
抗原和靶标
Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
- O43347 MSI1H_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43347 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| R197 | Methylation | Uniprot | |
| R199 | Methylation | Uniprot | |
| R201 | Methylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot |
研究背景
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Cytoplasm. Nucleus.
Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
The first RNA recognition motif binds more strongly to RNA compared to the second one.
Belongs to the Musashi family.
研究领域
· Genetic Information Processing > Translation > mRNA surveillance pathway.
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