(4)
(2)
| 产品: | TXNIP 抗体 |
| 货号: | DF7506 |
| 描述: | Rabbit polyclonal antibody to TXNIP |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 50 kDa; 44kD(Calculated). |
| 蛋白号: | Q9H3M7 |
| RRID: | AB_2841006 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7506, RRID:AB_2841006.
展开/折叠
EST01027; HHCPA78; THIF; Thioredoxin binding protein 2; Thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; TXNIP; TXNIP_HUMAN; Upregulated by 1,25 dihydroxyvitamin D 3; VDUP1; Vitamin D3 up-regulated protein 1;
抗原和靶标
- Q9H3M7 TXNIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H3M7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Sumoylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K19 | Sumoylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K100 | Sumoylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K115 | Sumoylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K117 | Sumoylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K140 | Sumoylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K163 | Sumoylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K167 | Sumoylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K212 | Sumoylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K228 | Sumoylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K233 | Sumoylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| K287 | Sumoylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| T348 | Phosphorylation | Uniprot | |
| T349 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| Y378 | Phosphorylation | Uniprot | |
| T379 | Phosphorylation | Uniprot |
研究背景
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
Cytoplasm.
Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.
Belongs to the arrestin family.
研究领域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
文献引用
Application: IHC Species: Mouse Sample:
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