(3)
(6)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7545, RRID:AB_2841044.
展开/折叠
Cas1; CAT; CATA_HUMAN; Catalase; Cs1; MGC138422; MGC138424;
抗原和靶标
- P04040 CATA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P04040 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| R47 | Methylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| S114 | O-Glycosylation | Uniprot | |
| T115 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Q05655 (PRKCD) | Uniprot |
| Y231 | Phosphorylation | P42684 (ABL2) , P00519 (ABL1) , A0A173G4P4 (Abl fusion) | Uniprot |
| C232 | S-Nitrosylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K237 | Acetylation | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| S254 | O-Glycosylation | Uniprot | |
| Y260 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| Y308 | Phosphorylation | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| Y379 | Phosphorylation | Uniprot | |
| Y386 | Phosphorylation | A0A173G4P4 (Abl fusion) , P42684 (ABL2) , P00519 (ABL1) | Uniprot |
| S422 | Phosphorylation | Uniprot | |
| Y425 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot | |
| C460 | S-Nitrosylation | Uniprot | |
| K468 | Acetylation | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| K476 | Acetylation | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot |
研究背景
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
The N-terminus is blocked.
Peroxisome.
Homotetramer.
Belongs to the catalase family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Carbohydrate metabolism > Glyoxylate and dicarboxylate metabolism.
· Metabolism > Global and overview maps > Carbon metabolism.
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
文献引用
Application: WB Species: human Sample: HConFs
限制条款
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