产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7562, RRID:AB_2841056.
展开/折叠
Casein kinase 2 beta polypeptide; Casein kinase II beta subunit; Casein kinase II subunit beta; CK II beta; CK2B; CK2N; CSK2B; CSK2B_HUMAN; CSNK 2B; csnk2b; G5A; MGC138222; MGC138224; Phosvitin; Protein G5a;
抗原和靶标
- P67870 CSK2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P67870 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) , P67870 (CSNK2B) | Uniprot |
| S3 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) , P67870 (CSNK2B) | Uniprot |
| S4 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| R92 | Methylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| Y108 | Phosphorylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K139 | Acetylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| Y144 | Phosphorylation | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| K147 | Acetylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| R178 | Methylation | Uniprot | |
| R186 | Methylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| K208 | Methylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S209 | Phosphorylation | P06493 (CDK1) | Uniprot |
| K212 | Acetylation | Uniprot | |
| K212 | Sumoylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T213 | Phosphorylation | O14757 (CHEK1) | Uniprot |
翻译修饰 - P67870 作为激酶
| Substrate | Site | Source |
|---|---|---|
| O95863 (SNAI1) | S92 | Uniprot |
| P04637-1 (TP53) | T18 | Uniprot |
| P08473 (MME) | S6 | Uniprot |
| P17509-1 (HOXB6) | S214 | Uniprot |
| P35222 (CTNNB1) | S29 | Uniprot |
| P35222 (CTNNB1) | T102 | Uniprot |
| P35222 (CTNNB1) | T112 | Uniprot |
| P35568 (IRS1) | S24 | Uniprot |
| P35568 (IRS1) | T88 | Uniprot |
| P35568 (IRS1) | S99 | Uniprot |
| P35568 (IRS1) | S330 | Uniprot |
| P35568 (IRS1) | T811 | Uniprot |
| P38398-3 (BRCA1) | S468 | Uniprot |
| P38398-8 (BRCA1) | S1525 | Uniprot |
| P49427 (CDC34) | S203 | Uniprot |
| P49427 (CDC34) | S222 | Uniprot |
| P49427 (CDC34) | S231 | Uniprot |
| P49427 (CDC34) | T233 | Uniprot |
| P49427 (CDC34) | S236 | Uniprot |
| P55010 (EIF5) | S174 | Uniprot |
| P55010 (EIF5) | S389 | Uniprot |
| P55010 (EIF5) | S390 | Uniprot |
| P55957-1 (BID) | T59 | Uniprot |
| P55957 (BID) | S64 | Uniprot |
| P67870 (CSNK2B) | S2 | Uniprot |
| P67870 (CSNK2B) | S3 | Uniprot |
| Q01105-2 (SET) | S9 | Uniprot |
| Q13158 (FADD) | S200 | Uniprot |
| Q13422 (IKZF1) | S13 | Uniprot |
| Q13422 (IKZF1) | T23 | Uniprot |
| Q13422 (IKZF1) | S63 | Uniprot |
| Q13422 (IKZF1) | S101 | Uniprot |
| Q13422 (IKZF1) | S295 | Uniprot |
| Q16625-1 (OCLN) | T404 | Uniprot |
| Q16625-1 (OCLN) | S408 | Uniprot |
| Q99523 (SORT1) | S825 | Uniprot |
| Q9UBF6-3 (RNF7) | T10 | Uniprot |
| Q9Y5B0-4 (CTDP1) | S575 | Uniprot |
| Q9Y5B0 (CTDP1) | S740 | Uniprot |
研究背景
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Phosphorylated by alpha subunit.
Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.
Belongs to the casein kinase 2 subunit beta family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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