HES1 Antibody - #DF7569

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产品: HES1 抗体
货号: DF7569
描述: Rabbit polyclonal antibody to HES1
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
蛋白号: Q14469
RRID: AB_2841062

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   规格 价格 库存
 50ul RMB¥ 1500 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
HES1 Antibody detects endogenous levels of total HES1.
RRID:
AB_2841062
引用格式: Affinity Biosciences Cat# DF7569, RRID:AB_2841062.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

bHLHb39; C-HAIRY1; c-hairy1A; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1 (Drosophila); Hairy and enhancer of split 1; Hairy homolog (Drosophila); Hairy homolog; Hairy like; Hairy, Drosophila, homolog of; Hairy-like protein; Hairy/enhancer of split, Drosophila, homolog of, 1; HAIRY1; HES-1; hes1; Hes1 hairy and enhancer of split 1 (Drosophila); HES1_HUMAN; HHL; HL; HRY; MGC129109; OTTHUMP00000209031; RHL; Transcription factor HES-1;

抗原和靶标

免疫原:

A synthesized peptide derived from human HES1, corresponding to a region within the internal amino acids.

基因/基因ID:
HES1(3280)

研究领域

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.

· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

文献引用

1). Kindlin-3 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial Infarction. Journal of cellular and molecular medicine, 2025 (PubMed: 40099947) [IF=5.3]
2). TMT-based quantitative proteomics analysis reveals the role of Notch signaling in FAdV-4-infected LMH cell. Frontiers in Microbiology, 2022 (PubMed: 36187945) [IF=5.2]
3). Notch1 contributes to TNF-α-induced proliferation and migration of airway smooth muscle cells through regulation of the Hes1/PTEN axis. International Immunopharmacology, 2020 (PubMed: 32871474) [IF=4.8]

Application: WB    Species: mouse    Sample: ASM cells

Fig. 5.| Notch1 knockdown decreased Hes1 and increased PTEN expression in TNF-α-induced ASM cells. ASM cells were transfected with NC or Notch1 siRNA for 48 h and then stimulated with TNF-α for 24 h. (D, E) Protein expression of Hes1 was examined by western blot.
4). Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways. Journal of ethnopharmacology, 2023 (PubMed: 37263315) [IF=4.8]
5). Neural stem cell-derived exosomes regulate neural stem cell differentiation through miR-9-Hes1 axis. Frontiers in Cell and Developmental Biology, 2021 (PubMed: 34055767) [IF=4.6]

Application: WB    Species: mouse    Sample: NSCs

FIGURE 7 | Hes1 expression is negatively regulated by miR-9 in NSCs.(C) Representative western blotting results showing the expression of Hes1 and β-actin proteins in either agomiR-C- or agomiR-9-transfected NSCs.
6). Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation. Brain Sciences, 2023 (PubMed: 36979321) [IF=3.3]

Application: WB    Species: Mouse    Sample: hippocampal tissue

Figure 6 Minocycline alleviates sevoflurane-induced neuroinflammation via Notch signaling suppression: (A) Cell immunofluorescence was performed to assess Notch signaling-associated proteins in BV2 cells of each group. Scale bar, 20 μm; (B–G) Immunoblot detection of Notch1, cleaved Notch1, and Hes1 in BV2 cells and hippocampal tissue specimens. β-actin was utilized for normalizing data quantitated by densitometry with ImageJ. Data are mean ± SEM.
7). The regulatory roles of VEGF-Notch signaling pathway on aplastic anemia with kidney deficiency and blood stasis. JOURNAL OF CELLULAR BIOCHEMISTRY, 2019 (PubMed: 30230583) [IF=3.0]

Application: WB    Species: human    Sample: HUVECs

FIGURE 5| The expression of VEGF‐Notch signaling pathway related proteins (VEGF, VEGFR, Notch‐1, Jagged1, Delta‐like1, and hes1)in HUVECs cocultured with VEGF/Notch shRNA transfected BMSCs (n = 3). *P < 0.05 vs HUVECs (normal control); #P < 0.05 vs BMSC + NC shRNA + HUVEC. BMSC, bone marrow mesenchymal stem cell; HUVEC, human umbilical vein endothelial cell; NC, normal control; shRNA, short hairpin RNA; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor
8). Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway. BMC gastroenterology, 2024 (PubMed: 39695403) [IF=2.4]
9). Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia. Journal of integrative neuroscience, 2024 (PubMed: 38419443) [IF=1.8]

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