(3)
(2)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7585, RRID:AB_2841076.
展开/折叠
95 alpha chain; 95; CD 11c; CD11 antigen like family member C; CD11 antigen-like family member C; CD11c; CD11c antigen; Complement component 3 receptor 4 subunit; CR4; Integrin alpha X; Integrin alpha X chain; Integrin alpha-X; Integrin aX; Integrin subunit alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit; ITAX_HUMAN; ITGAX; LEU M5 alpha subunit; Leu M5; Leukocyte adhesion glycoprotein p150 95 alpha chain; Leukocyte adhesion glycoprotein p150; Leukocyte adhesion receptor p150 95; Leukocyte adhesion receptor p150; Leukocyte surface antigen p150 95 alpha subunit; Leukocyte surface antigen p150 alpha subunit; Myeloid membrane antigen alpha subunit; p150 95 integrin alpha chain; p150; p150/95; SLEB6;
抗原和靶标
- P20702 ITAX_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANGQIAPENGTQTPSPPSEK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P20702 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N61 | N-Glycosylation | Uniprot | |
| N392 | N-Glycosylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| S673 | Phosphorylation | Uniprot | |
| S674 | Phosphorylation | Uniprot | |
| N697 | N-Glycosylation | Uniprot | |
| N735 | N-Glycosylation | Uniprot | |
| N899 | N-Glycosylation | Uniprot | |
| S1158 | Phosphorylation | Uniprot |
研究背景
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Membrane>Single-pass type I membrane protein.
Predominantly expressed in monocytes and granulocytes.
Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Belongs to the integrin alpha chain family.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
文献引用
Application: WB Species: Mouse Sample: RAW264.7 cells
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