产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7620, RRID:AB_2841107.
展开/折叠
FLJ16496; MGC149829; MGC50337; OTTHUMP00000082667; OTTHUMP00000227400; STX4-interacting protein; STXB4_HUMAN; Stxbp4; Synip; Syntaxin 4 interacting protein; Syntaxin 4-interacting protein; Syntaxin binding protein 4; Syntaxin-binding protein 4;
抗原和靶标
- Q6ZWJ1 STXB4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQKS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6ZWJ1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | P31751 (AKT2) | Uniprot |
| T151 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| K323 | Ubiquitination | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| Y391 | Phosphorylation | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| T446 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| T465 | Phosphorylation | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| S545 | Phosphorylation | Uniprot |
研究背景
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity).
Cytoplasm.
Interacts with STX4A.
限制条款
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