ARHGAP5 Antibody - #DF7649

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产品: ARHGAP5 抗体
货号: DF7649
描述: Rabbit polyclonal antibody to ARHGAP5
应用: WB IHC IF/ICC
反应: Human
预测: Pig, Zebrafish, Sheep, Rabbit, Dog, Chicken
分子量: 172 kDa; 172kD(Calculated).
蛋白号: Q13017
RRID: AB_2841126

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(100%), Zebrafish(91%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(91%)
克隆:
Polyclonal
特异性:
ARHGAP5 Antibody detects endogenous levels of total ARHGAP5.
RRID:
AB_2841126
引用格式: Affinity Biosciences Cat# DF7649, RRID:AB_2841126.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ARHGAP 5; ARHGAP5; p190 B; p190 RhoGAP; Rho GTPase activating protein 5; RhoGAP 5; RhoGAP; RhoGAP5;

抗原和靶标

免疫原:
Uniprot:

Q13017(RHG05_HUMAN) >>Visit HPA database.

基因/基因ID:
ARHGAP5(394)
表达:
Q13017 RHG05_HUMAN:

Detected in skin fibroblasts (at protein level) (PubMed:8537347).

序列:
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLNWSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEPMVPLQLPPPLQPQLIQPQLQTDPLGII

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Sheep
100
Dog
100
Rabbit
100
Zebrafish
91
Chicken
91
Horse
0
Bovine
0
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q13017 作为底物

Site PTM Type Enzyme
S12 Phosphorylation
S16 Phosphorylation
S21 Phosphorylation
T23 Phosphorylation
T199 Phosphorylation
T289 Phosphorylation
Y306 Phosphorylation P06213 (INSR)
K314 Acetylation
K321 Acetylation
K327 Ubiquitination
K394 Ubiquitination
K533 Ubiquitination
S540 Phosphorylation
S590 Phosphorylation
T591 Phosphorylation
K724 Ubiquitination
S765 Phosphorylation
S862 Phosphorylation
S948 Phosphorylation
S951 Phosphorylation
S968 Phosphorylation
S981 Phosphorylation
Y1019 Phosphorylation
T1024 Phosphorylation
K1053 Ubiquitination
K1060 Ubiquitination
S1088 Phosphorylation
Y1091 Phosphorylation
K1102 Ubiquitination
Y1104 Phosphorylation
S1105 Phosphorylation
Y1109 Phosphorylation P12931 (SRC) , Q13882 (PTK6)
S1115 Phosphorylation
S1124 Phosphorylation
T1129 Phosphorylation
S1138 Phosphorylation
T1159 Phosphorylation
T1171 Phosphorylation
S1173 Phosphorylation
S1176 Phosphorylation
S1184 Phosphorylation
S1195 Phosphorylation
S1202 Phosphorylation
T1206 Phosphorylation
T1217 Phosphorylation
S1218 Phosphorylation
S1396 Phosphorylation

研究背景

功能:

GTPase-activating protein for Rho family members.

细胞定位:

Cytoplasm. Cell membrane>Peripheral membrane protein.
Note: Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Detected in skin fibroblasts (at protein level).

亚基结构:

May interact with RASA1/p120GAP.

蛋白家族:

The pG1 pseudoGTPase domain does not bind GTP.

研究领域

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Organismal Systems > Immune system > Leukocyte transendothelial migration.   (View pathway)

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