| 产品: | PPP1R1A 抗体 |
| 货号: | DF7662 |
| 描述: | Rabbit polyclonal antibody to PPP1R1A |
| 应用: | WB |
| 反应: | Human, Monkey |
| 预测: | Dog |
| 分子量: | 27 kDa; 19kD(Calculated). |
| 蛋白号: | Q13522 |
| RRID: | AB_2841136 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7662, RRID:AB_2841136.
展开/折叠
I 1; I-1; I1; Inhibitor 1; IPP 1; IPP-1; IPP1; Ppp1r1a; PPR1A_HUMAN; Protein phosphatase 1 regulatory (inhibitor) subunit 1A; Protein phosphatase 1 regulatory subunit 1A; Protein phosphatase inhibitor 1;
抗原和靶标
- Q13522 PPR1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13522 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T35 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S46 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | P17612 (PRKACA) , P27361 (MAPK3) , Q00535 (CDK5) , P17252 (PRKCA) | Uniprot |
| T75 | Phosphorylation | P17252 (PRKCA) , P17612 (PRKACA) | Uniprot |
| T78 | Phosphorylation | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot |
研究背景
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Phosphorylation of Thr-35 is required for activity.
Interacts with PPP1R15A.
Belongs to the protein phosphatase inhibitor 1 family.
研究领域
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Nervous system > Long-term potentiation.
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