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| 产品: | ABCG1 抗体 |
| 货号: | DF7693 |
| 描述: | Rabbit polyclonal antibody to ABCG1 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 110 kDa; 76kD(Calculated). |
| 蛋白号: | P45844 |
| RRID: | AB_2841164 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7693, RRID:AB_2841164.
展开/折叠
ABC transporter 8; ABC8; ABCG1; ABCG1_HUMAN; ATP-binding cassette sub family G member 1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub family G WHITE member 1; homolog of Drosophila white; MGC34313; White protein homolog; White protein homolog ATP binding cassette transporter 8; WHITE1; WHT1;
抗原和靶标
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
- P45844 ABCG1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P45844 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K54 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| T99 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| K376 | Ubiquitination | Uniprot |
研究背景
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.
Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus membrane>Multi-pass membrane protein. Cell membrane.
Note: Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
Homodimer; disulfide-linked. Homooligomer. May form heterodimers with several heterologous partners of the ABCG subfamily. Interacts with CAV1; this interaction regulates ABCG1-mediated cholesterol efflux.
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
研究领域
· Environmental Information Processing > Membrane transport > ABC transporters.
文献引用
Application: WB Species: Mice Sample: RAW264.7 cells
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