产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7708, RRID:AB_2841177.
展开/折叠
Avian erythroblastosis virus E-26 (v-ets) oncogene related; D030036I24Rik; Erg 3; Erg; ERG/EWS fusion gene, included; ERG/FUS fusion gene, included; ERG/TMPSSR2 fusion gene, included; ERG_HUMAN; ERG1, included; ERG2, included; ets related; ETS-related gene; KCNH2; Oncogene ERG; p55; TMPRSS2/ERG fusion; transcriptional regulator ERG (transforming protein ERG); Transcriptional regulator ERG; Transforming protein ERG; v ets avian erythroblastosis virus E26 oncogene; v ets avian erythroblastosis virus E26 oncogene related; v ets erythroblastosis virus E26 oncogene homolog; v ets erythroblastosis virus E26 oncogene like; v ets erythroblastosis virus E26 oncogene like isoform 2; v-ets erythroblastosis virus E26 oncogene; v-ets erythroblastosis virus E26 oncogene homolog (avian); V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e;
抗原和靶标
- P11308 ERG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P11308 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T4 | Phosphorylation | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S45 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S46 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| Y48 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K99 | Acetylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y259 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S285 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| S413 | Phosphorylation | Uniprot |
研究背景
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
Nucleus. Cytoplasm.
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.
Belongs to the ETS family.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Specific types > Prostate cancer. (View pathway)
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