| 产品: | 67kDa Laminin Receptor 抗体 |
| 货号: | DF7710 |
| 描述: | Rabbit polyclonal antibody to 67kDa Laminin Receptor |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 33 kDa; 33kD(Calculated). |
| 蛋白号: | P08865 |
| RRID: | AB_2841179 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7710, RRID:AB_2841179.
展开/折叠
34/67 kDa laminin receptor; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin binding protein; Colon carcinoma laminin-binding protein; LAMBR; Laminin receptor 1; Laminin-binding protein precursor p40; LAMR 1; LamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; Multidrug resistance associated protein MGr1 Ag; Multidrug resistance associated protein MGr1Ag; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; p40; Ribosomal Protein SA; rpsA; RSSA_HUMAN; SA;
抗原和靶标
- P08865 RSSA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08865 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| Y39 | Phosphorylation | Uniprot | |
| K40 | Acetylation | Uniprot | |
| K40 | Methylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| K52 | Acetylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K57 | Acetylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| K89 | Acetylation | Uniprot | |
| K89 | Methylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| T104 | Phosphorylation | Uniprot | |
| T125 | Phosphorylation | Uniprot | |
| T135 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| Y156 | Phosphorylation | Uniprot | |
| C163 | S-Nitrosylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| R180 | Methylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| K212 | Sumoylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K224 | Sumoylation | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| T241 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot |
研究背景
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
(Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.
(Microbial infection) Acts as a receptor for the Dengue virus.
(Microbial infection) Acts as a receptor for the Sindbis virus.
(Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.
(Microbial infection) Acts as a receptor for the pathogenic prion protein.
(Microbial infection) Acts as a receptor for bacteria.
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Cell membrane. Cytoplasm. Nucleus.
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane.
Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
(Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9.
(Microbial infection) 67LR interacts with envelope protein of dengue virus.
(Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus.
Belongs to the universal ribosomal protein uS2 family.
研究领域
· Genetic Information Processing > Translation > Ribosome.
限制条款
产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.