(2)
(4)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7743, RRID:AB_2841210.
展开/折叠
4933419D20Rik; AA986696; BCG induced integral membrane protein 103; BCG induced integral membrane protein BIGMo-103 (Up-regulated by BCG-CWS) (Hypothetical protein); LIV-1 subfamily of ZIP zinc transporter 6; LZT Hs6; MGC108852; PP3105; SLC39A8; Solute carrier family 39 (zinc transporter), member 8 (SLC39A8); Solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; zinc transporter ZIP8; ZIP8; Zrt- and Irt-like protein 8;
抗原和靶标
Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
- Q9C0K1 S39A8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9C0K1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S275 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| T424 | Phosphorylation | Uniprot |
研究背景
Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.
Membrane>Multi-pass membrane protein.
Note: Associated with the lysosomal/endosomal compartment following transfection.
Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
Belongs to the ZIP transporter (TC 2.A.5) family.
研究领域
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
文献引用
Application: IF/ICC Species: Human Sample: ESCC
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