BIGM103 Antibody - #DF7743

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产品: BIGM103 抗体
货号: DF7743
描述: Rabbit polyclonal antibody to BIGM103
应用: WB IHC IF/ICC
反应: Human
预测: Pig, Horse, Rabbit, Dog
分子量: 50 kDa; 50kD(Calculated).
蛋白号: Q9C0K1
RRID: AB_2841210

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(90%), Horse(80%), Rabbit(80%), Dog(80%)
克隆:
Polyclonal
特异性:
BIGM103 Antibody detects endogenous levels of total BIGM103.
RRID:
AB_2841210
引用格式: Affinity Biosciences Cat# DF7743, RRID:AB_2841210.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

4933419D20Rik; AA986696; BCG induced integral membrane protein 103; BCG induced integral membrane protein BIGMo-103 (Up-regulated by BCG-CWS) (Hypothetical protein); LIV-1 subfamily of ZIP zinc transporter 6; LZT Hs6; MGC108852; PP3105; SLC39A8; Solute carrier family 39 (zinc transporter), member 8 (SLC39A8); Solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; zinc transporter ZIP8; ZIP8; Zrt- and Irt-like protein 8;

抗原和靶标

免疫原:
Uniprot:

Q9C0K1(S39A8_HUMAN) >>Visit HPA database.

基因/基因ID:
SLC39A8(64116)
表达:
Q9C0K1 S39A8_HUMAN:

Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.

序列:
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
90
Horse
80
Dog
80
Rabbit
80
Bovine
70
Sheep
70
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9C0K1 作为底物

Site PTM Type Enzyme
S275 Phosphorylation
S278 Phosphorylation
K284 Ubiquitination
S288 Phosphorylation
T424 Phosphorylation

研究背景

功能:

Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.

细胞定位:

Membrane>Multi-pass membrane protein.
Note: Associated with the lysosomal/endosomal compartment following transfection.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.

蛋白家族:

Belongs to the ZIP transporter (TC 2.A.5) family.

研究领域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

文献引用

1). Identification and analysis of a prognostic ferroptosis and iron-metabolism signature for esophageal squamous cell carcinoma. Journal of Cancer (PubMed: 35371305) [IF=3.9]

Application: IF/ICC    Species: Human    Sample: ESCC

Figure 4 Immunofluorescence of PRNP (green), SLC39A8 (red), LCN2 (red), ATP6V0A1 (green), SLC3A2 (red), and SLC39A14 (green) in ESCC samples and normal tissues.
2). Effects of Long-Term Dietary Zinc Oxide Nanoparticle on Liver Function, Deposition, and Absorption of Trace Minerals in Intrauterine Growth Retardation Pigs. BIOLOGICAL TRACE ELEMENT RESEARCH (PubMed: 36585599) [IF=3.9]

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