产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7783, RRID:AB_2841244.
展开/折叠
G protein beta 2 subunit; G protein subunit beta 2; G protein subunit beta-2; GBB2_HUMAN; Gnb2; Gnb2l1; Guanine nucleotide binding protein beta 2 subunit; Guanine nucleotide binding protein G I G S G T beta 2 subunit 2; Guanine nucleotide binding protein G protein beta polypeptide 2; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; OTTHUMP00000174601; OTTHUMP00000174602; RACK1; Receptor for activated C kinase; Receptor of activated protein kinase C 1; Signal transducing guanine nucleotide binding regulatory protein beta; Transducin beta chain 2;
抗原和靶标
- P62879 GBB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P62879 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| R15 | Methylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| C25 | S-Nitrosylation | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| K57 | Acetylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K78 | Acetylation | Uniprot | |
| Y85 | Phosphorylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| C204 | S-Nitrosylation | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| Y239 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| C317 | S-Nitrosylation | Uniprot |
研究背景
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Cytoplasm>Perinuclear region.
G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A.
Belongs to the WD repeat G protein beta family.
研究领域
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Human Diseases > Substance dependence > Alcoholism.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Nervous system > GABAergic synapse.
· Organismal Systems > Nervous system > Dopaminergic synapse.
· Organismal Systems > Endocrine system > Relaxin signaling pathway.
限制条款
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