Presenilin 2 Antibody - #DF7809

Fig. 4 T. denticola induces Aβ accumulation by up regulating BACE1  and PS1, KMI-1303 and DAPT can inhibit the efect of T. denticola on Aβ. a  RNA was extracted from mouse hippocampus, and the expression of genes related to Aβ accumulation was detected by qPCR. The values are shown as the mean±SD of three independent experiments. *p<0.05, **p<0.01, ***p<0.001, N=4 mice per group. b, c, d, e Protein expression levels of APP, BACE1, PS1 and PS2 in the hippocampus were examined by western blotting. The results of the quantitative analysis of the blots; results are presented as means±std. dev,*p<0.05, **p<0.01, ***p<0.001, N=4 mice per group. f Images represent the results of three repeated experiments. N2a cells were treated with 107  CFU  T. denticola or 1 μmol/L DAPT and 107  CFU T. denticola or 1 μmol/L KMI1303 and 107   CFU T. denticola. T. denticola -infected N2a cells were stained by an anti-Aβ1–42 protein antibody and viewed under a fuorescence microscope. g The results of IF are expressed as means±std. dev., *p<0.05, ***p<0.001