产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7835, RRID:AB_2841275.
展开/折叠
5730471K09Rik; Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Cadherin associated protein; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNN protein; CTNNBL 1; Ctnnbl1; dJ633O20.1; FLJ21108; NAP; Nuclear associated protein; nuclear protein NAP; Nuclear-associated protein; NYD SP19; OTTMUSP00000016933; P14; P14L; PP8304; RP5 1118M15.1; Testis development protein NYD SP19; Testis development protein NYD-SP19;
抗原和靶标
Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.
- Q8WYA6 CTBL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVGELLSYQPNRGTKRPRDDEEEEQKMRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQKRILGLLENF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8WYA6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| R13 | Methylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| K56 | Acetylation | Uniprot | |
| R65 | Methylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| T398 | Phosphorylation | Uniprot | |
| T399 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K437 | Ubiquitination | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| R469 | Methylation | Uniprot | |
| T477 | Phosphorylation | Uniprot | |
| K527 | Acetylation | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| Y536 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot |
研究背景
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.
Nucleus.
Cytoplasm.
Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.
The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.
研究领域
· Genetic Information Processing > Transcription > Spliceosome.
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